- Hornsby, in 1924, finishes the season with a .424 batting average to lead the National League. The Cardinal second baseman easily outdistances Zack Wheat, who finishes second in the race batting .375 for the Dodgers.
- In 1930, Dizzy Dean pitches his first career complete game defeated the Pirates 3-1 on a 3-hitter.
- Harry Walker hits .363 to win the National League batting title in 1947 and during the season he is traded to the Phillies, after appearing in just ten games with the World Champion Cardinals, a team in which he played a pivotal role. The ‘Hat’s older brother, Dixie, also won a batting crown the Senior Circuit with a .357 BA for Brooklyn in 1944.
- The Cardinals selected Fred Norman off waivers from the Los Angeles Dodgers in 1970.
- In a 1979 twin bill at Busch Stadium, Cardinal infielder Garry Templeton collects three hits against the Mets to become the first player to get 100 hits from each side of the plate. The St. Louis shortstop bats just right-handed during the last nine games to establish the unprecedented switch-hitting mark.
- Jack Fournier 1889
- Todd Worrell 1959
- Mike DeJean 1970
- Nick Greenwood 1987
- Al Shaw 1907
- Johnny Beazley 1941
- Don Bollweg 1950
- Marc Hill 1973
- Kim Seaman 1979
- George Paynter 1950