- In 1926, catcher Bob Farrell is named NL MVP, Later in December, he is named the manager to replace Rogers Hornsby.
- The New York Giants purchased Bob Bowman from the Cardinals in 1940.
- Cardinals purchased Debs Garms from the Pittsburgh Pirates in 1941.
- The Cardinals, in 1946, purchased Tommy O’Brien from the Pittsburgh Pirates.
- Ellis Kinder is selected off waivers by the Cardinals from the Boston Red Sox in 1955.
- The Cardinals acquire Curt Flood from the Reds in 1957 along with Joe Taylor, in exchange for Marty Kutyna, Willard Schmidt and Ted Wieand.
- Stan Musial resigns in 1967, his one and only season as the Cardinals General Manager and is replaced by Bing Devine. Musial stays with the organization as senior vice president and consultant.
- The Oakland Athletics purchased Mudcat Grant from the Cardinals in 1969.
- In 1969, the Cardinals purchased Bill Dillman from the Baltimore Orioles.
- In 1973, the Los Angeles Dodgers traded Pete Richert ito the St. Louis Cardinals for Tommie Agee.
- The Chicago White Sox traded Jim Otten in 1977 to the Cardinals for Stan Butkus.
- The New York Mets, in 1978, traded Tom Grieve and Kim Seaman to the Cardinals for Pete Falcone.
- The Cardinals trade Carson Kelly, Luke Weaver, and Andy Young along with a pick in the Competitive Balance Draft to the Diamondbacks for Paul Goldschmidt in 2018.
- Patsy Tebeau (1864) –Tebeau is one of just over a dozen managers to have won at least 400 games in the 19th century. In his 13-year MLB career, Tebeau played 1,167 games and batted .279 with 27 home runs and 735 runs batted in.His managing record was 726–583–30.He was known for verbally abusing umpires and opposing players, for which he was criticized by journalists. He played for the Perfectos in 1899 and the Cardinals in 1900.
- Carey Selph (1901) – He began his professional career in 1926 with the Fort Smith Twins, scoring an amazing 169 runs. He was soon acquired by the St. Louis Cardinals, and finished the season with the Syracuse Chiefs. After spending 1928 with the Houston Buffaloes in the Texas League, he made his major league debut in 1929 for the Cardinals. In 25 games, Selph played mostly as a second baseman, batting .235. After two seasons back in the minor leagues with the Buffaloes, Selph was drafted from the Cardinals by the Chicago White Sox on September 30, 1931 in the Rule 5 draft.
- Gus Mancuso (1905) – was an American professional baseball player, coach, scout and radio sports commentator. He played as a catcher in Major League Baseball with the St. Louis Cardinals (1928, 1930–32, 1941–42). A .265 lifetime hitter.
- Don Padgett (1911) -In 1939, Padgett, while serving as backup catcher to Cardinals receiver Mickey Owen — batted a lofty .399 in 92 games played, 257 plate appearances and 233 at bats, but did not qualify for the National League batting championship. All told, in eight Major League seasons he played in 699 games and had 1,991 At Bats, 247 Runs, 573 Hits, 111 Doubles, 16 Triples, 37 Home Runs, 338 RBI, 6 Stolen Bases, 141 Walks, .288 Batting Average, .336 On-base percentage, .415 Slugging Percentage, 827 Total Bases and 10 Sacrifice Hits.
- Jack Urban (1928) –Appearing in only eight games for St. Louis, Urban allowed 18 hits, seven walks and 11 earned runs in 102⁄3 innings for a 9.28 ERA. He played his final game on August 6, 1959 against the Pittsburgh Pirates. Although he entered the majors with a bang, he left them with a bust – in only one-third of an inning, he allowed a total of five runs.
- John Lovett 1937 –