The Cardinals went 83-79 during the season and finished third in the National League East division, 13 games behind the NL East champion Pittsburgh Pirates.
November 25, 1991: Ken Hill was traded by the St. Louis Cardinals to the Montreal Expos for Andrés Galarraga.
January 15, 1992: Ozzie Canseco signed as a Free Agent with the St. Louis Cardinals.
Starting pitcher Bob Tewksbury posted his best season with a 2.16 ERA, second-best in the NL, and topped the league walks per nine innings and strikeout-to-walk ratio. He finished third in the Cy Young voting. Catcher Tom Pagnozzi posted the sixteenth best single-season fielding mark (tied) in history for his position (.9987).
The team led the National League in batting average at .262 but was just sixth in runs scored. Their 3.38 ERA was fourth in the league.