- In 1903, the Cardinals trade future Hall of Fame right-hander Mordecai “Three Fingers” Brown and catcher Jack O’Neill to the Cubs in exchange for backstop Larry McLean and Jack Taylor, a righty who will set the record for consecutive complete-games in one season next year with 39 when he compiles a 20-19 record for the Redbirds. Three-finger Brown will post a 188-86 (.686) record, including six consecutive seasons of 20+ wins, during his ten-year tenure with Chicago.
- The Cardinals traded Art Fromme and Ed Karger in 1908 to the Cincinnati Reds for Admiral Schlei.
- Cardinals traded Red Murray, Bugs Raymond and Admiral Schlei to the New York Giants for Roger Bresnahan in 1908.
- Cardinals traded Bob Harmon, Ed Konetchy and Mike Mowrey to the Pittsburgh Pirates for Art Butler, Cozy Dolan, Dots Miller, Hank Robinson and Chief Wilson in 1913.
- The Milwaukee Brewers traded David Green, Dave LaPoint, Sixto Lezcano and Lary Sorensen to the St. Louis Cardinals in 1980 for Rollie Fingers, Ted Simmons and Pete Vuckovich
- The Cardinals traded Steve Barnard (minors) and George Hendrick in 1984 to the Pittsburgh Pirates for Brian Harper and John Tudor
- Cardinals in 2010 traded Brendan Ryan to the Seattle Mariners for Maikel Cleto.
- In 2012, the Cardinals traded Skip Schumaker to the Los Angeles Dodgers for Jake Lemmerman.
- Clyde Kluttz- 1917
- Bill Howerton- 1921