- In 1989, the Cardinals signed Danny Cox as a free agent.
- Signed Cesar Izturis as a free agent in 2007.
- Signed Ruben Gotay as a free agent in 2009.
- Jeff Suppan was granted free agency in 2009.
- Brad Penny, Jason LaRue, and Dennys Reyes of the St. Louis Cardinals granted free agency 2010.
- The Cardinals in 2010, traded Blake Hawksworth to the Los Angeles Dodgers for Ryan Theriot
- Jake Westbrook, in 2013. was granted free agency.
- Reuben Ewing (1899)
- Bob Tewksbury (1960)
- Jim Davis 1995
- Bernie Creger 1997